Extermination
Kill 50 aliens
Annihilation
Kill 100 aliens
Nuclear Devastation
Kill 250 aliens
Hippy-Stomper
Foot stomp 12 aliens
Judge, Jury, Executioner
Execute 20 aliens
Trapper
Kill 10 aliens with Trip Mines
Freeze Well!
Kill 15 frozen aliens
Road Rage
Kill 15 aliens with the monster truck
Fork the Pork
Kill 6 aliens with the forklift
Dead Useful
Kill 10 aliens with environmental explosives
Tosser... in the Literal Sense
Kill 10 aliens with tossed objects
Duke Angry, Duke Smash!
Kill 15 aliens with melee attacks while on steroids
Noms
Eat 10 pieces of food during the SP campaign
On the Noggin'
Kill 30 aliens with headshots
Substance Abuser
Drink beer while on steroids or vice-versa in SP
Natural Disaster 3x
Kill 3 aliens at once
Full Body Tourettes
Get knocked down 10 times
Turd Burglar
Find and steal a piece of poo
I Need a Towel
Get hit by 10 Pregnator bombs
Baron von Nukem
Shoot down 20 alien fighters
I Need a Date
Look at every page of a calendar in SP
Sticky Bomb Like You!
Put a Trip Mine on a live alien
Big Guns, Big Ships
Blow up 5 enemy gunships or dropships
Air-Duke
Win air hockey with a score of 7-0 in the strip club
Balls of Steel
Earn a 1,000,000 pinball score in SP
Flagon of Chuckles
Drink a beer in SP
Juiced
Take steroids in SP
He's Got a Hologram!
Use a Holoduke in SP
Drawrings
Doodle something on the whiteboard in SP
I Am All That Is Man
Discover all ego cap rewards
Gunslinger
Carry the gold pistol through the whole SP campaign
Piece of Cake
Complete the SP campaign on Easy Difficulty
Let's Rock
Complete the SP campaign on Normal Difficulty
Come Get Some
Complete the SP campaign on Hard Difficulty
Damn, I'm Good
Complete the SP campaign on Insane Difficulty
Special Thanks
Watch the credits all the way through
Bucket Head
Find all 3 helmets in the SP campaign
Call Waiting
Listen to all phone messages
Party Animal
Drink all of the beers in the strip club
Pescaphobe
Kill all of the catfish in the underwater level
Sunday, Black Sunday
Shoot down the blimp above the stadium
Nobody Likes a Whiner
Knock out the talent at the talk show
Lots of Whacking
Win a game of Alien Abortion in the strip club
Companion Barrel
Unlock the secret closet at the end of the Forkstop
One-Eyed Freak
Defeat the Cycloid
Pit Champion
Defeat the Battlelord in Las Vegas
Not Bad for a Human
Defeat the Alien Queen
A Good Dam Fight
Defeat the Battlelord on the Hoover Dam
Octacide
Defeat the Octaking
Beating the One-Eyed Worm
Defeat the Energy Leech