Easy
Beat the game on Easy setting
Medium
Beat the game on Medium setting
Hard
Beat the game on Hard setting
Monster Massacre
Kill 1000 monsters in combat
Zombie Zapper
Kill 200 Zombies in combat
Chaos Crusher
Kill 100 Agents in combat
Rat Remover
Kill 50 Rats in combat
Mutant Masher
Kill 50 Mutants in combat
Meat Murderer
Kill the Meat Machine 25 times in combat
Slime Slapper
Kill 10 Slimes in combat
Darkness Destroyer
Kill Darkness 25 times on any difficulty
Bleedin'
Take 200 points of physical damage
Glowin'
Take 250 points of radiation damage
Turnin'
Take 100 points of venom damage
Death and Glory
Discover all 9 Outcomes
Fisto
Punch Darkness... Right in the face
Trap Trickster
Use items to bypass 50 traps
The New York Chainsaw Massacre
Kill 2000 enemies in combat
Chain of Skulls
Kill one of every enemy type in a single game
Throne of skulls
Kill one of every enemy type in a single game on Classic difficulty
Don't bring a Chainsaw to a Knife fight
Have your Chainsaw destroyed while having the Knife still in your inventory
Seems Ironic
Kill the Suicide Cultist with an explosive weapon
Just in Slime
Find a way to use Time Grenades on the Slime in the second deck to send it back in time